异质呈现和血清学在肌痛性痛风的患者呈现与缺食症
Clare Moffatt1, Pranati Pillutla1, Payam Soltanzadeh2
1Department of Head & Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, U.S.A.
The Laryngoscope
|July 1, 2024
概括
骨髓灰质炎 (MG) 可能导致吞问题. 早期诊断和检测乙胆受体 (AChR),MuSK和LRP4抗体对于有效治疗这种神经肌肉疾病至关重要.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 骨髓灰质炎 (MG) 是一种自身免疫性神经肌肉结合障碍.
- 脑膜炎可以表现为耳鼻喉科症状,如食障碍.
- 在MG中,独特的呈现和罕见的血清学并未完全描述.
研究的目的:
- 为了描述MG的独特表现,呈现出初级失调症.
- 突出这些患者的诊断血清学谱.
- 强调MG作为无法解释的喉乱的差异诊断.
主要方法:
- 对被诊断患有MG.MG.的失消症患者的回顾性审查.
- 收集的数据:人口统计,临床表现,吞研究,血清学,成像,治疗和反应.
- 包括办公室内吞评估和修改的吞研究.
主要成果:
- 五名患者符合纳入标准;四名患者表现为缺食症,一名患者表现为缺食症和缺音症.
- 吞研究显示了喉的弱点和残留物; 一名患者经历了肌危机.
- 血清学包括乙胆受体 (AChR),肌肉特异激酶 (MuSK) 和低密度脂蛋白受体相关蛋白4 (LRP4) 抗体.
结论:
- 对于无法解释的喉功能障碍患者,应考虑使用MG.
- AChR抗体查很重要,但在血清阴性病例中,对MuSK和LRP4的测试至关重要.
- 及时诊断和治疗,包括类固醇和皮里多斯提格,导致症状改善.
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