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极度早产新生儿的低血和晚发性败血症:一个病例控制研究
Elizabeth Fisher1, Eveline Staub1,2
1Neonatal Intensive Care Unit, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Journal of paediatrics and child health
|July 1, 2024
概括
极度早产婴儿的低血是常见的,但与晚发性败血症 (LOS) 没有联系. 低静脉摄入蛋白质可能会增加这些脆弱的新生儿的感染风险.
科学领域:
- 新生儿医学 新生儿医学
- 儿童传染病 儿童传染病
- 营养科学 营养科学
背景情况:
- 晚发性败血症 (LOS) 是极其早产婴儿的一个重大问题.
- 这些新生儿容易患上重新养综合征和相关的低酸血症.
- 在这个人群中,低酸血和LOS之间的关系需要研究.
研究的目的:
- 确定低酸盐血症是否使极早新生儿易患晚发性败血症.
- 探索这种高风险群体感染的潜在风险因素.
主要方法:
- 在澳大利亚NICU (2016-2020) 进行了一项回顾性病例控制研究.
- 病例是怀孕29周之前出生的新生儿,他们患有LOS或局部感染.
- 每个病例与基于妊娠年龄和出生日期的两个对照组相匹配.
主要成果:
- 病例在出生时较小 (767g vs 901g),但其他情况与对照组相比较.
- 低度血症在病例中更频繁 (26%对15%),尽管在统计学上不显著 (P=0.18).
- 增加第一周的静脉注射蛋白质摄入量显示出对LOS (OR=0.9,P=0.04) 的保护作用.
结论:
- 低酸血症,通常与再养综合征有关,在极度早产婴儿中很常见,并且经常被忽视.
- 在这项研究中,没有发现低酸血症和晚发性败血症之间的关联.
- 在第一周内静脉输入较低水平的蛋白质可能是感染的独立风险因素.
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