睡眠和体力活动行为集群与墨西哥青少年表观遗传年龄加速之间的关联
Margaret Banker1, Erica C Jansen, Jaclyn M Goodrich2
1Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI.
Medicine and science in sports and exercise
|July 1, 2024
概括
青少年的睡眠和体育活动模式影响生物衰老. 特定的行为,如充足的睡眠与低活动加快了衰老,而女性的睡眠不足减缓了它,突出了性别和青春期的差异.
科学领域:
- 儿科表观遗传学 儿科表观遗传学
- 行为科学是一种行为科学.
- 时间生物学 时间生物学
背景情况:
- 通过DNA甲基化测量的表观遗传衰老反映了生物年龄.
- 睡眠和体力活动等行为可能会影响表观遗传衰老.
- 对这些行为和儿童表观遗传衰老的研究是有限的.
研究的目的:
- 调查身体活动和睡眠行为与青少年表观遗传衰老之间的关联.
- 为了解释儿科表观遗传衰老研究中的相关行为.
主要方法:
- 472名墨西哥城青少年 (14.5 ± 2.09岁) 接受了DNA甲基化分析和7天的手腕动图.
- 克米恩斯的聚类发现了三个行为模式:"睡眠短/久坐度高"",睡眠充足/迟到/低MVPA"和"睡眠充足/高MVPA".
- 线性回归检查了群集和九个表观遗传钟之间的关联,并调整了共变量.
主要成果:
- "充足的睡眠/迟到的时间/低MVPA"集群显示,与"充足的睡眠/高MVPA"相比,衰老加速 (GrimAge时钟).
- 在"充足的睡眠/晚期时间/低MVPA"组中,在更成熟的青少年中观察到加速表观遗传衰老.
- "睡眠不足/久坐不动"组的女性表现出衰老减缓 (Wu儿科钟).
结论:
- 与睡眠和体力活动相关的行为模式与青少年的表观遗传衰老有差异性关联.
- 这些关联因青春期状态和性别而异.
- 儿科特有的表观遗传钟可能会产生不同的结果,这需要进一步的研究.
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