关于怀孕时间的父亲药物开放模式
Isobel McEwen1, Krista F Huybrechts2, Loreen Straub2
1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Paediatric and perinatal epidemiology
|July 1, 2024
概括
超过三分之一的父亲在怀孕前使用了处方药. 众所周知,其中一些药物会损害胎儿发育,这凸显了对父亲药物暴露风险的更多研究的需要.
科学领域:
- 生殖健康 生殖健康
- 药理学 药理学是指药理学的学科.
- 甲状腺学 甲状腺学
背景情况:
- 关于产前药物暴露的研究传统上侧重于母亲的使用.
- 关于在精子生成过程中父亲使用药物的影响的数据有限.
- 识别常见的父性预孕药物使用对于未来的研究至关重要.
研究的目的:
- 为了确定在怀孕前的时期,父亲最常被处方的药物.
- 为研究优先事项提供有关父亲预孕药物暴露的信息.
主要方法:
- 利用MarketScan数据库 (2011-2020年) 对商业保险的美国个人.
- 确定的怀孕和估计的受孕日期.
- 将怀孕与父亲联系起来,并分析了怀孕前90天内处方药的使用情况.
主要成果:
- 超过140万例怀孕符合纳入标准,其中51.6%是与父亲有联系.
- 给父亲开放的顶级药物类别是精神药物 (8.66%),抗生素 (7.21%) 和止痛药 (6.82%).
- 常见的药物包括阿莫西西林,阿齐思罗米,弗卢蒂卡松和乙氨基/可. 值得注意的是,0.04%的受试者接受了mycophenolate,0.03%的受试者接受了methotrexate,0.02%的受试者接受了isotretinoin,这些药物已知具有胚胎毒性.
结论:
- 超过三分之一的父亲在怀孕前期填写了处方.
- 由于已知的胚胎毒性,一些分发的药物存在潜在风险.
- 需要进一步调查父亲暴露的致病性.
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