来自Myrica javanica的循环二甲基类:隔离,转化和生物活性评估
Dikhi Firmansyah1, Vienntiny Safrilianti Effendi1, Jilan Izdihar Fauziyyah1
1Organic Chemistry Research Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Bandung, Indonesia.
Natural product research
|July 1, 2024
概括
从Myrica javanica中分离出了三种周期性二甲基乙胺. 衍生品显示出增强的细胞毒性,而myricanol则表现出显著的自由基清除活性.
科学领域:
- 自然产品 化学 化学
- 药用化学 医学化学
- 植物化学 植物化学
背景情况:
- Myrica javanica是一种生物活性化合物的植物来源.
- 循环二甲基乙胺是一种具有潜在治疗应用的天然产品类别.
研究的目的:
- 从Myrica javanica中分离和表征周期性二甲基乙.
- 评估这些化合物及其衍生物的生物活性,包括细胞毒性和抗氧化能力.
主要方法:
- 从 Myrica javanica 树皮和树枝中分离出 1-3 种化合物.
- 迈里卡诺尔 (1) 的化学转化,以产生衍生品 4 和 5.
- 对小鼠白血病P-388细胞的细胞毒性测定.
- DPPH激素清除活动测定.
主要成果:
- 分离了myricanol (1),myricanone (2) 和porson (3),其中myricanol是主要成分.
- 衍生品5-prenylmyricanol (4) 和5-benzylmyricanol (5) 在高产量下进行了合成.
- 与myricanol (1) 相比,化合物4和5的细胞毒性增加了两倍 (IC50 = 12μM).
- 米里卡诺尔 (1) 显示出最高的自由基清除活性 (IC50 = 39.3 μM),突出其基组的作用.
结论:
- Myrica javanica产生的有价值的周期性二甲类化合物.
- 衍生可以增强myricanol的细胞毒性质.
- 米里卡诺尔具有显著的抗氧化能力,归因于其基组.
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