病原体基因组学在疫情调查中的应用
Benjamin J Parcell1, Kerry A Pettigrew2, Katarina Oravcova3
1Clinical Senior Lecturer and Honorary Consultant, Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK. bjparcell@dundee.ac.uk.
Methods in molecular biology (Clifton, N.J.)
|July 1, 2024
概括
全基因组测序 (WGS) 提供了一种强大的新方法,用于检测和管理涉及危险病原体的医院疫情. 这种方法通过能够更快,更准确地对抗多药耐药生物体 (MDROs) 进行干预,从而提高公共卫生.
科学领域:
- 微生物学 微生物学
- 公共卫生 公共卫生
- 基因组学就是基因组学.
背景情况:
- 涉及致病性,高病毒性或多耐药生物体 (MDROs) 的疫情对公共卫生构成重大风险,特别是在医院环境中.
- 易受伤害的群体,如免疫抑制个体,重症监护患者和新生儿,特别容易感染与医疗相关的感染.
- 快速而精确的疫情检测对于及时干预以控制临床环境中的传播至关重要.
研究的目的:
- 概述在医疗保健环境中实施全基因组测序 (WGS) 的具体程序和协议.
- 突出WGS在彻底改变疫情调查和管理方面的潜力.
- 用先进的WGS技术取代传统的基因型鉴定方法,以改善歧视.
主要方法:
- 审查和综合整个基因组测序技术当前的进展.
- 在临床疫情调查中应用WGS的实用协议的开发.
- 将WGS能力与传统的病原体歧视方法进行比较.
主要成果:
- 全基因组测序 (WGS) 的成本下降,容量增加,可复制性得到改善.
- 在疫情爆发期间,WGS为追踪病原体传播提供了增强的歧视能力.
- 已建立的协议有助于将WGS整合到医院常规感染控制实践中.
结论:
- 全基因组测序 (WGS) 准备在医疗保健环境中改变疫情调查.
- 实施WGS协议可以更有效地控制MDRO和其他危险的病原体.
- 医院疫情管理系统 (WGS) 为管理与医院疫情相关的公共卫生风险提供了比传统方法更好的替代方案.
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