第一个三个月的COVID-19疫苗接种和活产儿中主要的结构性出生缺陷
Elyse O Kharbanda1, Malini B DeSilva1, Heather S Lipkind2
1HealthPartners Institute, Minneapolis, Minnesota.
JAMA pediatrics
|July 1, 2024
概括
在怀孕期间接种COVID-19疫苗的第一季度信使RNA (mRNA) 并没有与活产婴儿的重大出生缺陷有关. 这项研究为孕妇提供了关于怀孕早期COVID-19疫苗安全性的保证.
科学领域:
- 生殖健康 生殖健康
- 疫苗安全问题 疫苗安全问题
- 儿科健康 儿科健康
背景情况:
- 建议在怀孕期间接种COVID-19疫苗,以减轻严重疾病和不良分娩结果的风险.
- 有限的数据存在关于在第一季度COVID-19疫苗接种后潜在的出生缺陷.
研究的目的:
- 为了评估活产婴儿在怀孕第一季度接触信使RNA (mRNA) COVID-19疫苗的选择性重大结构性出生缺陷的风险.
主要方法:
- 这是一项回顾性队列研究,利用疫苗安全数据链接中的8个卫生系统的数据.
- 包括2020年9月至2021年4月期间估计的最后一次月经期 (LMP) 的单独怀孕,导致活产.
- 通过使用稳定反向概率权衡,比较了第一季度接受mRNACOVID-19疫苗的母亲所产生的婴儿的主要结构性出生缺陷与第一季度未接种疫苗的婴儿.
主要成果:
- 该研究包括42,156名符合条件的怀孕;18.1%接受了第一季度mRNACOVID-19疫苗接种.
- 在加权后,接种疫苗和未接种疫苗的组之间,基线特征是可比的.
- 针对选择的主要结构性出生缺陷的调整后患病率为1.02 (95% CI,0.78-1.33),表明与第一季度疫苗接种没有显著关联.
结论:
- 怀孕期间对mRNA COVID-19疫苗的第一季度暴露与选择的主要结构性出生缺陷的风险增加无关.
- 调查结果支持在怀孕早期接种COVID-19疫苗的安全性,涉及主要结构异常.
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