肺部细分切除术后复发的长期结果和风险因素
Shinsuke Uchida1, Aritoshi Hattori1, Mariko Fukui1
1Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan.
概括
早期非小细胞肺癌的肺部细分切除术显示出良好的长期结果. 纯固体瘤与更高的复发率和降低的存活率有关.
科学领域:
- 胸部外科手术 胸部外科手术
- 手术瘤学手术瘤学
- 肺部医学 肺部医学
背景情况:
- 肺部细分切除术后的长期瘤结果尚不清楚.
- 确定复发风险因素对于优化治疗策略至关重要.
研究的目的:
- 为了研究临床I期非小细胞肺癌的肺部细分切除术后的长期预后.
- 为了评估与此程序后癌症复发相关的特定风险因素.
主要方法:
- 一组177名患有临床第一阶段非小细胞肺癌的患者在2008年至2012年期间接受了细分切除术.
- 卡普兰-梅尔分析和日志等级测试评估了总生存率 (OS) 和无复发生存率 (RFS) 在120.1个月的中位随访期间.
- 单变量和多变量分析确定了复发的预测因素.
主要成果:
- 5年的RFS为89.7%,10年的RFS为79.8%;5年的OS为90.9%,10年的OS为80.4%.
- 纯固体瘤的出现是复发的重要危险因素 (HR, 23.151; P = 0.005).
- 较高的PET/CT最大标准化吸收值与增加的复发率相关.
结论:
- 细分切除术为一些患有早期非小细胞肺癌的患者提供了可接受的长期瘤结果.
- 纯固体瘤的放射性外观是复发和降低存活率的关键预测因素,需要在治疗计划中仔细考虑.
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