70岁及以上的肺移植患者中期和长期死亡率的风险因素
Yining Pan1, Jiang Shi2,3, Xuan Li3
1First Clinical College, Guangzhou Medical University, Guangzhou, China.
概括
70岁以上患者的肺移植存活率受到接受者健康状况,供体状况和移植类型等因素的影响. 识别这些风险可以优化护理,并改善老年接受者的结果.
科学领域:
- 移植研究 移植研究
- 老年医学 老年医学
- 心胸外科手术是一项心胸手术.
背景情况:
- 肺移植越来越多地在70岁及以上的患者中进行.
- 关于影响这一群体生存的风险因素的数据有限.
- 识别这些因素对于改善患者的治疗结果至关重要.
研究的目的:
- 确定影响70岁及以上肺移植接受者的中长期死亡率的独立风险因素.
- 为优化这一群体的术后管理和治疗策略提供信息.
主要方法:
- 从2005年5月到2022年12月使用联合器官共享网络数据对70岁以上的肺移植接受者的分析.
- 排除多器官,二次移植,以及对随访的损失.
- 应用单变量和多变量考克斯回归模型来评估影响3年和5年死亡率的因素.
主要成果:
- 影响3年和5年死亡率的关键因素包括接受者总胆红素,ICU状态,供体糖尿病,细胞母细胞病毒 (CMV) 不匹配和单次肺移植.
- 西班牙裔/拉丁裔种族和缺血时间显著影响了3年死亡率.
- 接受者的年龄,糖尿病,移植前的氧化使用和肌素水平独特地影响了5年死亡率.
结论:
- 几个独立的风险因素影响了70岁以上的肺移植接受者的中长期存活率.
- 这些发现可以指导优化老年肺移植患者的治疗策略和术后护理.
- 在这个不断增长的患者群体中提高生存率是首要目标.
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