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二次结构和pH对聚乙烯糖醇-b-聚氨酸自组合的影响

Caixia Jiang¹, Chonghao Zhao¹, Peng Xu¹

¹Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.

Biomacromolecules

|July 1, 2024

概括

聚二次结构,如β片,直接自组装成纳米结构. 聚氨酸共聚合物根据它们的形状形成不同的纳米片和纳米纤维,显示出药物输送的潜力.

科学领域:

聚合物化学聚合物化学
材料科学材料科学材料科学
纳米技术纳米技术

背景情况:

多具有独特的二次结构 (随机线圈,α螺旋,β片) 影响链形状,刚性和可溶性.
这些结构性质决定了产生的纳米结构的自我组装行为和形态.
聚氨酸 (PTyr) 衍生的两性共聚物为研究自组装中的结构性质关系提供了一个平台.

研究的目的:

调查不同聚二次结构对聚氨酸衍生型两共聚合物的自我组装的影响.
合成和描述具有不同立体化学的聚乙烯糖醇-块聚-氨酸的块共聚合物.
探索pH诱导的二次结构变化如何影响自我组装和纳米结构形态.

主要方法:

聚乙烯糖醇-块-聚氨酸共聚合物的合成,通过环开聚合氨酸N-thiocarboxyanhydrides的聚合.
使用光谱技术对共聚物二次结构 (例如β-sheet,随机线圈) 的表征.
在不同pH条件下的水溶液中分析自我组装行为和纳米结构形态.

主要成果:

PEG-块-P ((l-Tyr) 具有β-片形状的自我组装成矩形纳米片.
PEG-block-P(dl-Tyr) 具有随机的线圈/β-sheet 含量,自组装成状的纳米纤维.
增加的pH值导致β-sheet含量减少和纳米结构改变 (纳米带,扭曲的纳米带).

结论:

PTyr片段的二次结构是自我组装路径和纳米结构形态学的关键决定因素.
通过对二次结构的控制,PTyr衍生的共聚物可以被设计成各种细丝状纳米结构.
这些发现有望为开发新型纳米结构,用于控制药物释放等应用.

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