尿路双A与高脂血症和所有原因死亡率的关联:NHANES 2003-2016年
Lijuan Guo1, Pin Zhao2, Shilong Xue2
1Department of Disease Prevention and Control, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
PloS one
|July 1, 2024
概括
尿中双A (BPA) 的升高与高脂血症的更高风险有关. 这种暴露还会增加患有高脂血症的个体的全因死亡风险.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 尿路双A (BPA) 和高脂血症之间的关联仍然不清楚.
- 关于尿路BPA对高脂血症患者死亡率的影响的研究有限.
研究的目的:
- 调查尿液BPA和高脂血症之间的关系.
- 评估尿液BPA对高脂血症患者全因死亡风险的影响.
主要方法:
- 使用国家健康和营养检查调查数据 (2003-2016).
- 采用多变量物流和考克斯回归分析.
- 分析了与超脂血症诊断和死亡率相关的尿BPA水平.
主要成果:
- 分析了8,983名参与者;70.3%的人患有高脂血症.
- 在超脂血症组中观察到尿液BPA水平较高 (3.87 ± 0.32对比2.98 ± 0.14,P = 0.01).
- 超脂血症的几率增加与更高的BPA三位数 (或1.28为三位数3).
- 尿液BPA升高与高脂血症患者全因死亡风险增加有关 (HR 1.20).
结论:
- 尿路BPA和高脂血症风险之间存在积极的关联.
- 尿液中的BPA与患有高脂血症的成年人全因死亡率的增加有显著联系.
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