半球功能组织,由自然主义神经成像揭示,在皮层切除的儿科患者中
Sophia Robert1,2, Michael C Granovetter1,2,3, Christina Patterson4
1Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213.
概括
儿童脑损伤表现出了显著的可塑性. 这项研究揭示了在大型皮质切除后的儿童的保存半球中广泛的功能连接减少,这表明大脑发生了显著的重组.
科学领域:
- 神经科学是一个神经科学.
- 儿科神经学 儿科神经学
- 脑部成像 脑部成像
背景情况:
- 儿童脑损伤可以诱导显著的神经可塑性.
- 之前的研究集中在靠近病变或在相反半球的大脑局部区域.
- 了解整个大脑的功能变化对于儿科治疗至关重要.
研究的目的:
- 通过全脑方法研究皮质可塑性,研究患有因而导致大片面皮质切除的儿童的皮质可塑性.
- 为了比较患者与匹配的对照者的保存半球中的功能连接 (FC).
主要方法:
- 使用功能磁共振成像 (fMRI) 扫描患者和对照者在观看电影时.
- 使用解剖图谱将保存的半球划分为180个和200个部分.
- 计算了地块 (地块边缘) 和大规模功能网络 (网络边缘) 之间的对联统计依赖.
主要成果:
- 与对照组相比,大片面皮层切除的患者表现出CF的广泛减少.
- 这些减少在网络内部连接中尤为突出.
- 个体患者的分析揭示了不同的术后连接特征,表明个性化的大脑可塑性.
结论:
- 大切除的儿科患者的保存半球显示出显著的,广泛的功能连接性改变.
- 这些大规模的网络差异可能代表了支持认知功能的适应性可塑性.
- 研究结果强调了手术干预后个性化神经可塑性变化的潜力.
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