多功能水凝的合理设计,针对糖尿病牙周炎的微环境
Miao Zhang1, Saisai Yan1, Jie Wang1
1The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China; Cancer Institute, Qingdao University, Qingdao 266071, China.
International immunopharmacology
|July 1, 2024
概括
在糖尿病患者中治疗牙周炎是具有挑战性的,因为这种疾病会加剧骨质损失. 本综述侧重于针对糖尿病牙周炎的四个微环境的水凝策略.
科学领域:
- 牙周病药物 牙周病药物
- 生物材料科学是生物材料的科学.
- 内分泌学 在内分泌学.
背景情况:
- 牙周炎是成年人牙脱落的主要原因,其特点是慢性炎症.
- 糖尿病会显著恶化牙周炎,加速骨再吸收,并使治疗复杂化.
- 糖尿病和牙周炎之间的双向关系是一个持续的临床挑战.
研究的目的:
- 审查牙周炎的病因和病原性,特别是在糖尿病的背景下.
- 分析糖尿病牙周炎的四个关键病理微环境:高葡萄糖,细菌感染,炎症和骨质损失.
- 总结一下针对这些微环境的基于水凝的治疗策略的最新进展.
主要方法:
- 关于牙周炎和糖尿病的综合文献综述.
- 对糖尿病牙周炎病理微环境的分析.
- 专注于水凝设计和针对性治疗的应用策略.
主要成果:
- 糖尿病和牙周炎之间的相互作用的详细摘要.
- 鉴定了糖尿病牙周炎影响的四个关键的微环境.
- 基于水凝的创新治疗方法的概述,以解决这些特定的病理状况.
结论:
- 水凝策略对管理糖尿病牙周炎复杂的病理微环境有希望.
- 通过水凝针对高葡萄糖,细菌感染,炎症和骨质损失提供了新的治疗途径.
- 对水凝设计和临床应用的进一步研究对于有效治疗糖尿病牙周炎至关重要.
相关概念视频
Teeth
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...


