格拉尼尼:一种食中的基素,作为癌症进展中信号通路的调节器
Naresh Narayanan Prabakaran1, Suvaasni Prasad1, Kiruthigaa Krishnan1
1Department of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur, Chennai 603203, Tamil Nadu, India.
格拉尼尼 (GN) 是一种天然的ellagitannin,显示出作为抗癌剂的显著潜力. 本次审查强调了其通过诱导亡和调节关键癌症途径来对抗各种癌症的能力.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
背景情况:
- 癌症对全球健康造成重大负担,因为其治疗需求尚未得到满足.
- 具有强大的抗癌活性的新型生物活性分子实体 (BMEs) 对于有效的疾病管理至关重要.
- 埃拉吉坦宁 (Ellagitannin Geraniin,简称GN) 是一种天然存在的BME,具有已证明的治疗潜力.
研究的目的:
- 审查2005年至2023年关于Geraniin (GN) 抗癌潜力的科学文献.
- 研究GN的药理优势,代谢物概况和癌症中的分子标.
- 巩固GN作为一种新型抗癌治疗剂的证据.
主要方法:
- 进行了对科学文献的叙事审查.
- 在Scopus,科学网,谷歌学者和PubMed中使用特定的关键字进行了搜索.
- 52项相关研究从一个最初的430篇文章中被选中.
主要成果:
- 实质性的体外,体内和临床证据支持GN对各种癌症的疗效.
- 机理学研究揭示了GN在促进亡和表现出抗炎和抗血管原性质方面的作用.
- GN调节了癌症特征的关键信号通路.
结论:
- 格拉尼尼 (GN) 具有有利于癌症治疗的类药理学和分子性质.
- 作为一个有前途和有效的抗癌剂,GN显示出显著的潜力.
- 需要进一步的研究和临床试验,才能充分确定GN的治疗作用.
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