在MASLD和MASLD相关的肝细胞癌中,肠道微生物组,宿主遗传和表观遗传修饰之间的相互作用
Suki Ha1, Vincent Wai-Sun Wong1, Xiang Zhang2
11Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.
Gut
|July 1, 2024
概括
主体遗传和肠道微生物相互作用,影响代谢功能障碍相关的脂肪性肝病 (MASLD). 了解这种双向关系为MASLD和相关的肝病提供了新的治疗策略.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 遗传学和表观遗传学
背景情况:
- 与代谢功能障碍相关的脂肪酸性肝病 (MASLD) 呈现出一系列的肝病,从脂肪酸症到肝细胞癌 (HCC).
- 新出现的证据表明,在MASLD的发病过程中,宿主遗传/表观遗传因素和肠道微生物群之间存在复杂的相互作用.
研究的目的:
- 审查肠道微生物组,宿主遗传学和MASLD和MASLD相关的HCC中的表观遗传变化的作用.
- 阐明肠道微生物组与宿主遗传/表观遗传之间的双向影响.
- 强调这种相互作用对MASLD预防和治疗的重要性.
主要方法:
- 文献综述综合了当前的研究成果.
- 分析研究调查宿主遗传学,表观遗传学和肠道微生物群落在MASLD的分析.
- 检查宿主因子和肠道微生物群之间的双向通信通路.
主要成果:
- 主体遗传学塑造了肠道微生物组的组成.
- 肠道微生物群及其代谢物可以诱导表观遗传修饰,影响MASLD的发展.
- 在宿主遗传/表观遗传影响微生物组的情况下存在双向关系,反之亦然.
结论:
- 肠道微生物组与宿主遗传/表观遗传因素之间的复杂关系在MASLD中至关重要.
- 准这种肠主轴为MASLD和相关疾病提供了有前途的治疗途径.
- 对这种相互联系的进一步研究对于有效的MASLD预防和治疗策略至关重要.
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