大麻使用和老年人急性术后疼痛结果:倾向性匹配的回顾性队列研究
Ruba Sajdeya1, Masoud Rouhizadeh2, Robert L Cook2
1University of Florida, Gainesville, Florida, USA rubasajdeya@ufl.edu.
Regional anesthesia and pain medicine
|July 1, 2024
概括
老年人使用大麻与更高的术后疼痛和阿片类药物需求有关. 这一发现凸显了这一人群接受手术的潜在风险.
科学领域:
- 老年医学 老年医学
- 疼痛管理 疼痛管理
- 药理学 药理学是指药理学的学科.
背景情况:
- 在老年人群中,大麻的使用率正在上升.
- 大麻对老年人手术后疼痛的影响尚不清楚.
- 这项研究调查了大麻消费与老年人手术疼痛结果之间的关系.
研究的目的:
- 确定大麻使用与术后疼痛强度之间的关联.
- 评估大麻使用对老年人手术后阿片类药物消费的影响.
主要方法:
- 使用佛罗里达大学健康 (2018-2020) 电子健康记录进行了一项回顾性队列研究.
- 倾向性得分匹配 (1:3比) 用于比较22476名老年手术患者中的大麻使用者和非使用者.
- 通过临床笔记和结构化数据的自然语言处理识别了大麻使用情况;使用国防和退伍军人疼痛评级表 (DVPRS) 测量疼痛,并在手术后24小时内将阿片类药物剂量作为口服吗啡等价物 (OME) 测量.
主要成果:
- 该研究包括504名患者 (126名大麻使用者,378名非使用者),平均年龄为69岁.
- 与非使用者相比,大麻使用者报告的平均DVPRS疼痛得分 (4.68比3.88) 显著更高.
- 大麻使用者在手术后24小时内还需要显著增加的口服总吗啡相当量 (OME) (42.50毫克与30.00毫克相比).
结论:
- 老年人使用大麻与术后疼痛增加有关.
- 使用大麻的老年人可能需要在手术后服用更高剂量的阿片类药物.
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