Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

iPS Cell Differentiation01:22

iPS Cell Differentiation

2.7K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Unprecedented rearranged triterpenoids with seven-membered rings from <i>Camellia formosensis</i> and structurally diverse bioactive triterpenoids.

RSC advances·2026
Same author

CXCL14 promotes osteosarcoma cell migration and invasion by inducing epithelial-to-mesenchymal transition.

International journal of medical sciences·2026
Same author

High-Intensity thermal stress enhances adoptive NK-cell cytotoxicity in poorly differentiated hepatocellular carcinoma.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·2026
Same author

Atomic-Level CuO<sub>x</sub>-CoO<sub>x</sub>-Pd Interfacial Engineering Enables Hierarchical Synergy for High-Efficiency ORR Pathways and Boosted Power Output in Alkaline Fuel Cells.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Impact of deubiquitination of Epstein-Barr virus Rta and Zta on lytic development.

Microbiology spectrum·2026
Same author

A Novel Partial EMT-Associated Transcriptomic Signature for Prognostic Stratification in Ovarian Cancer.

Oncology research·2026

相关实验视频

Updated: Jun 22, 2025

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
13:47

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models

Published on: March 29, 2019

9.5K

使用纳米点平台改善iPSC差异化

Men Yee Chiew1,2, Erick Wang2,3, Kuan-Chun Lan4

  • 1Center for Regenerative Medicine and Cellular Therapy, National Yang Ming Chiao Tung University, Hsinchu, 300, Taiwan, ROC.

ACS applied materials & interfaces
|July 1, 2024
PubMed
概括
此摘要是机器生成的。

这项研究使用纳米点平台来研究诱导多能干细胞 (iPSC) 分化成心肌细胞的过程. 研究人员确定了可以增强这一过程的药物,为干细胞治疗开发提供了一个新的工具.

关键词:
心肌细胞分化机制的心肌细胞分化机制差异化效率的差异化效率.药物查对药物进行查.iPSC 的差异化差异化.纳米拓学是指纳米拓学.

更多相关视频

Flow Cytometric Analysis of Multiple Mitochondrial Parameters in Human Induced Pluripotent Stem Cells and Their Neural and Glial Derivatives
06:09

Flow Cytometric Analysis of Multiple Mitochondrial Parameters in Human Induced Pluripotent Stem Cells and Their Neural and Glial Derivatives

Published on: November 8, 2021

4.2K
Conversion of Human Induced Pluripotent Stem Cells iPSCs into Functional Spinal and Cranial Motor Neurons Using PiggyBac Vectors
07:33

Conversion of Human Induced Pluripotent Stem Cells iPSCs into Functional Spinal and Cranial Motor Neurons Using PiggyBac Vectors

Published on: May 1, 2019

11.3K

相关实验视频

Last Updated: Jun 22, 2025

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
13:47

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models

Published on: March 29, 2019

9.5K
Flow Cytometric Analysis of Multiple Mitochondrial Parameters in Human Induced Pluripotent Stem Cells and Their Neural and Glial Derivatives
06:09

Flow Cytometric Analysis of Multiple Mitochondrial Parameters in Human Induced Pluripotent Stem Cells and Their Neural and Glial Derivatives

Published on: November 8, 2021

4.2K
Conversion of Human Induced Pluripotent Stem Cells iPSCs into Functional Spinal and Cranial Motor Neurons Using PiggyBac Vectors
07:33

Conversion of Human Induced Pluripotent Stem Cells iPSCs into Functional Spinal and Cranial Motor Neurons Using PiggyBac Vectors

Published on: May 1, 2019

11.3K

科学领域:

  • 干细胞生物学 干细胞生物学
  • 生物技术是生物技术.
  • 纳米技术 纳米技术

背景情况:

  • 诱导多能干细胞 (iPSC) 分化是复杂且具有挑战性的研究.
  • 了解控制iPSC分化的机制对于临床应用至关重要.

研究的目的:

  • 用一个新的纳米点平台阐明iPSC差异化机制.
  • 确定能够调节和提高心肌细胞分化效率的小分子药物.

主要方法:

  • 开发一个具有不同纳米点直径的纳米点平台.
  • 在平台上培养iPSC并应用心肌细胞分化协议.
  • 对基因表达特征的分析和候选药物的鉴定.

主要成果:

  • 鉴定了与心肌细胞差异化相关的基因表达特征.
  • 重新设计的BRD K98,以抑制分化;NSC-663284,卡尔摩和KPT-330增强了分化.
  • 相关的细胞外矩阵改造基因具有差异化效率;细胞周期基因显示了对比的趋势.

结论:

  • 纳米点平台有效地揭示了复杂的iPSC分化机制.
  • 已识别的药物可以优化iPSC差异化,以便在潜在的临床应用中使用.
  • 突出显示了未来研究的关键基因组 (ECM重塑,细胞循环).