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Updated: Jun 22, 2025

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IFNγ-IL12轴调节代谢功能障碍相关的脂肪性肝病中的细胞间交叉

Randall H Friedline1, Hye Lim Noh1, Sujin Suk1,2

  • 1Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.

Nature communications
|July 1, 2024
PubMed
概括

干扰素- (IFNγ) 在髓状细胞中的信号驱动着与肥胖相关的胰岛素抵抗和肝炎. 阻止这种途径可以防止脂肪肝疾病和纤维化,突出IFNγ-IL12轴作为代谢功能障碍相关的脂肪肝炎 (MASH) 的治疗标.

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