皮层和皮层下大脑网络预测普遍的心率
Amy Isabella Sentis1,2, Javier Rasero2,3,4, Peter J Gianaros2,5
1Medical Scientist Training Program, University of Pittsburgh and Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Psychophysiology
|July 2, 2024
概括
较高的大脑区域影响静止心率,影响心血管疾病的风险. 这项研究使用fMRI和机器学习来识别大脑网络,预测健康成年人的心率变化.
科学领域:
- 神经科学是一个神经科学.
- 心血管生理学心血管生理学
- 计算生物学 计算生物学
背景情况:
- 休息心率是心血管疾病 (CVD) 的危险因素.
- 心率的自主控制主要与大脑干有关.
- 在心率调节中,大脑上皮层和下皮层区域在心率调节中的作用不太清楚.
研究的目的:
- 为了确定预测健康成年人静止心率变化的大脑网络.
- 探索心率调节的神经支柱,超越大脑干.
- 研究大脑活动作为心血管风险生物标志物的潜力.
主要方法:
- 使用功能磁共振成像 (fMRI) 来测量全脑血液动力学信号.
- 采用机器学习算法,从fMRI数据中预测瞬间心脏周期 (心跳间隔).
- 分析了来自两个独立数据集的基于任务和静止状态的fMRI数据,并进行了重复测量.
主要成果:
- 机器学习模型成功地从个人内部和跨个体的全脑fMRI数据中预测了瞬间的心脏周期.
- 参与者内部模型的预测准确度最高.
- 确定了与内脏功能相关的皮质和皮质下大脑区域网络,作为心脏周期变化的可靠预测器.
结论:
- 高层次的大脑网络有助于调节心率.
- 这些发现支持了心血管健康中大脑与心脏相互作用的概念.
- 这项研究为开发针对心血管疾病风险的基于大脑的生物标志物提供了潜在的途径.
相关概念视频
Correlation between ECG and Cardiac Cycle
4.2K
The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle.
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
4.2K
Factors Influencing Heart Rate
2.6K
The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
2.6K
Regulation of Heart Rates
1.7K
The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
1.7K
Cardiac Output I:Effect of Heart Rate on Cardiac Output
732
Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
732
Neural Regulation of Blood Pressure
2.7K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
2.7K
Electrophysiology of Normal Cardiac Rhythm
3.1K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
3.1K


