炎症性肠道疾病儿童的Helicobacter Pylori感染:一个前性的多中心研究
Emanuele Dilaghi1, Enrico Felici2, Edith Lahner1
1Department of Medical-Surgical Sciences and Translational Medicine, Sant'Andrea Teaching Hospital, Sapienza University of Rome, Rome, Italy.
在患有或没有炎症性肠病 (IBD) 的儿科患者中,Helicobacter pylori (Hp) 感染率相似. 在IBD患者的诊断时或治疗后,HP感染没有影响疾病活动或严重程度得分.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 关于Helicobacter pylori (Hp) 感染与儿科炎性肠病 (IBD) 之间的关联仍在争论中.
- 这项研究研究了新诊断的儿科IBD患者与对照者的HP感染流行率.
研究的目的:
- 为了确定与非IBD对照组相比,儿科IBD患者的Hp感染率.
- 分析Hp感染和非感染IBD患者在基线和根除疗法 (ET) 后1年随访期间的临床活性指数 (CAI) 和内镜严重性评分 (ESS) 差异.
主要方法:
- 诊断IBD是根据波尔图标准进行的.
- 胃镜检查在基线和1年后对所有患者进行.
- 临床活性和内镜严重程度使用验证的评分 (克罗恩病的PCDAI/SES-CD,性结肠炎的PUCAI/UCEIS) 进行评估.
主要成果:
- 包括76名IBD患者和148名非IBD患者.
- 在两组中,HP感染的患病率相似 (IBD患者的9.2%,非IBD患者的12.2%,p=0.5065).
- 在Hp阳性和Hp阴性IBD患者之间在基线或ET后1年随访时没有发现CAI或ESS的显著差异.
结论:
- 在儿科IBD和非IBD患者中,hp感染的发生率并不不同.
- 在诊断时,HP感染状态不会影响IBD活动或严重程度.
- 在IBD患者中,HP的根除疗法在一年的随访中不会导致疾病活动或严重程度的恶化.
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