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基于因克雷丁的治疗和糖尿病足和相关事件的风险
Nikki C C Werkman1,2,3, Johanna H M Driessen1,2,3, Olaf H Klungel1
1Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht, The Netherlands.
Diabetes, obesity & metabolism
|July 2, 2024
概括
双类酶-4抑制剂 (DPP4-Is) 和类似葡萄糖类-1受体激活剂 (GLP1-RAs) 显示糖尿病足 (DFU) 和相关并发症的风险降低. 这表明,基于英克雷丁的疗法可能有利于患有DFU风险的个体.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病足 (DFU) 是2型糖尿病的一个重要并发症.
- 有效的管理策略对于预防DFU及其严重后果至关重要,包括下肢截肢 (LLA).
研究的目的:
- 评估二二甲酶-4抑制剂 (DPP4-Is) 和类似葡萄糖-1受体激动剂 (GLP1-RAs) 对DFU发生率的影响.
- 评估这些基于隐素的疗法对DFU相关结果 (如LLA,住院和死亡率) 的影响.
主要方法:
- 使用临床实践研究Datalink Aurum数据库进行的一项倾向得分匹配的队列研究.
- 在2型糖尿病患者中,DPP4-Is与硫尿素和GLP1-RAs与胰岛素的新用户之间的比较.
- 考克斯的比例危险模型被用来估计DFU和相关结果的危险比率.
主要成果:
- 与使用硫基尿素相比,DPP4-I使用与DFU风险降低有关 (HR 0.88).
- 使用GLP1-RA表明,短期 (HR 0.44) 和长期 (HR 0.74) DFU与胰岛素的风险显著降低.
- DPP4-Is和GLP1-RA都与较低的住院和死亡风险有关,GLP1-RA也显示LLA风险降低.
结论:
- 包括DPP4-Is和GLP1-RA在内的基于胰岛素的疗法与患糖尿病足的风险降低有关.
- 这些发现表明,基于因克雷丁的治疗在减轻风险糖尿病人群中DFU及其相关不良结果方面可能具有保护作用.
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