主观认知问题,APOE ε4,PTSD症状,以及老年退伍军人的痴呆风险
Zoe E Neale1,2,3, Jennifer R Fonda4,5,6, Mark W Miller1,4
1National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, 150 South Huntington Ave (116B-2), Boston, MA, 02130, USA.
Alzheimer's research & therapy
|July 2, 2024
概括
主观认知问题 (SCC) 与退伍军人的阿尔茨海默病和相关痴呆症 (ADRD) 风险增加有关. 创伤后应激障碍 (PTSD),创伤性脑损伤 (TBI) 和APOE ε4是老年退伍军人ADRD的主要危险因素.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 精神病学是一个精神病学.
背景情况:
- 创伤后应激障碍 (PTSD) 和创伤性脑损伤 (TBI) 与认知问题以及阿尔茨海默病和相关痴呆症 (ADRD) 的风险增加有关.
- 重叠的症状使得早期的ADRD检测变得复杂,特别是在同时出现的精神疾病或头部受伤时.
- 创伤后应激障碍,头部损伤,主观认知问题 (SCC) 和ADRD遗传风险之间的相互作用仍未得到充分研究,特别是在不同的人群中.
研究的目的:
- 调查VA百万退伍军人计划 (MVP) 内的不同祖先群体中痴呆风险因素 (APOE ε4,PTSD,TBI) 和SCC之间的关联.
- 根据PTSD,TBI,APOE ε4和SCC使用电子健康记录来评估65岁及以上退伍军人患ADRD的风险.
主要方法:
- 利用了VA百万退伍军人计划 (MVP) 的数据,包括140,921名欧洲人,15,788名非洲人和8,064名西班牙裔祖先.
- 使用VA电子医疗记录进行了回顾性生存分析,以评估PTSD,TBI,APOE ε4和SCC与65岁以上退伍军人的ADRD转换之间的关联.
主要成果:
- 在所有祖先群体中,PTSD症状和可能的TBI与SCC积极相关.
- APOE ε4与欧洲祖先退伍军人中较大的SCC有关.
- 在所有组中,PTSD症状,APOE ε4和SCC都与ADRD风险有关;TBI也增加了欧洲祖先退伍军人的ADRD风险.
结论:
- 主观认知问题 (SCC) 作为老退伍军人中ADRD风险的有价值指标.
- 将SCC与遗传,临床和人口因素相结合,可以提高ADRD风险评估.
- 调查结果强调了考虑多种风险因素对预测多样化的退伍军人群体ADRD的重要性.
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