在唾液中获得的表观遗传分数与出生时的妊娠年龄有关
Katie Mckinnon1, Eleanor L S Conole2, Kadi Vaher1,3
1Centre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, 4-5 Little France Drive, Edinburgh, EH16 4UU, UK.
Clinical epigenetics
|July 2, 2024
概括
早产婴儿的低妊娠年龄 (GA) 与炎症蛋白质的表观遗传分数 (EpiScores) 发生变化有关. 社会经济地位 (SES) 显示较少的关联,表明炎症,而不是SES,是新生儿免疫失调的关键.
科学领域:
- 新生儿表观遗传学 新生儿表观遗传学
- 免疫系统的发展 免疫系统的发展
- 健康和疾病的发育起源.
背景情况:
- 表观遗传分数 (EpiScores) 是基于DNA甲基化 (DNAm) 的复杂特征的替代品,包括循环蛋白.
- 亲炎症性EpiScores与早产儿的大脑健康和炎症状况有关.
- 社会劣势可能会通过炎症影响儿童的发育,特别是在早产婴儿.
研究的目的:
- 调查早产,社会经济地位 (SES) 和与炎症相关的蛋白质变化之间的关联EpiScores.
- 探索炎症在调解SES对早产婴儿发育影响中的作用.
主要方法:
- 从332名新生儿的唾液样本中提取了104个蛋白质EpiScores.
- 分析了EpiScores与出生时妊娠年龄 (GA) 和SES之间的关联.
- 在调整新生儿发病率后,在早产子组中检查了EpiScore关联.
主要成果:
- 四十三个 (41%) 的EpiScore与出生时的低GA相关,包括免疫和神经发育蛋白质.
- 三个EpiScore显示了与SES或GA-SES相互作用的关联.
- 在早产婴儿中,在调整为败血症,支气管肺功能失调症,死角性肠球炎和组织学膜炎后,SES-EpiScore相关性并不显著.
结论:
- 低出生GA与一组EpiScores显著相关,富含炎症蛋白质,表明早产婴儿的免疫失调.
- SES与EpiScores的关联性有限,效果大小小,在调整并发症后不持续.
- 炎症似乎不太可能是SES在新生儿时期影响早产婴儿发育的主要途径.
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