特定于年龄和性别的急性中毒药物和影响神经系统的药物
Bita Mesgarpour1,2, Shabnam Faridfar3, Mahya Rezaei3
1Cochrane Iran Associate Centre, National Institute for Medical Research Development (NIMAD), Tehran, Iran. bmesgarpour@gmail.com.
BMC pharmacology & toxicology
|July 2, 2024
概括
由神经系统药物引起的急性中毒是常见的,特别是在年轻男性中故意服用甲过量. 片类药物和酒精中毒病例正在增加,而二胺类药物和抗抑郁药物的病例正在下降,非法药物导致大多数死亡.
科学领域:
- 毒理学 毒理学 毒理学
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 研究了神经系统药物和非法物质的急性中毒.
- 专注于德黑兰的Loghman Hakim医院,这是一个主要的毒理学转诊中心.
研究的目的:
- 分析急性中毒的流行,趋势和人口分布.
- 确定与神经系统毒剂诱导的中毒相关的特定药物和危险因素.
主要方法:
- 从2010年1月至2015年12月对患者病历的回顾性审查.
- 对由神经系统毒剂引起的中毒病例进行分析,检查年龄,性别和故意性.
主要成果:
- 包括29,083名患者 (57.27%男性);中位数年龄为29岁 (男性) 和26岁 (女性).
- 大多数中毒是故意的 (69.38%的男性,79.00%的女性). 阿尔普拉佐拉姆在女性中最常见,在男性中最常见的是甲.
- 片类药物,酒精和成障碍药物中毒增加;二和抗抑郁药物中毒减少. 男性的死亡率较高 (1.95%与0.56%相比).
结论:
- 甲中毒是经常发生的,特别是在年轻男性中,并且在很大程度上是故意的.
- 阿尔普拉佐拉姆和克罗纳泽帕姆中毒在分别20-29岁的女性和男性中很常见. 在老年人群中发现了片的使用.
- 非法药物,特别是片,造成了超过一半的死亡,强调了有针对性的预防计划的必要性.
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