神经调节4-ErbB4信号通路是由电刺激驱动的,以重塑棕色脂肪组织内置
Ziwei Yu1, Ting Zhang1, Xingyu Yang1
1Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing, China.
Diabetes, obesity & metabolism
|July 2, 2024
概括
电刺激 (ES) 通过BMP8B-NRG4-ErbB4通路重塑棕色脂肪组织 (BAT) 中的同情性内置. 这种方法增强了BAT热生成和新陈代谢,提供了潜在的治疗益处.
科学领域:
- 神经科学是一个神经科学.
- 代谢研究研究 代谢研究
- 身体生理学 身体生理学
背景情况:
- 棕色脂肪组织 (BAT) 在热生成和代谢调节中起着至关重要的作用.
- 交感内置是BAT功能的一个关键调节器.
- 规范不当的BAT有助于诸如肥胖等代谢障碍.
研究的目的:
- 在BAT中研究电刺激 (ES) 对交感内置的作用.
- 阐明潜在的分子机制,重点关注BMP8B-NRG4-ErbB4轴.
- 为了确定ES效应对BAT的体型依赖性.
主要方法:
- 建立高脂肪饮食 (HFD) 的小鼠模型.
- 测量BAT热生成和新陈代谢.
- 对交感神经活动 (SNA) 和中央神经通路的c-Fos免疫覆盖的电生理学记录.
- 使用ErbB4对抗性的BMP8B-NRG4-ErbB4轴的验证.
主要成果:
- 对前肢和腹部区域应用的ES显著增加了SNA,并改善了HFD诱导的BAT功能障碍.
- 脑中神经系统的影响由从中腹下丘脑 (VMH) 到脊髓中侧柱 (IML) 的神经通路进行介导.
- 在BAT中对外围ErbB4的抑制消除了ES诱导的热生成,代谢改善和SNA激活.
结论:
- 在BAT中,ES有效地重塑了交感内.
- NRG4-ErbB4信号通路对于ES介导的BAT改造至关重要.
- VMH神经活动是ES对BAT影响的组成部分,突出了神经代谢调节轴.
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