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Updated: Jun 22, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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1,2,3-基α-葡萄糖酶抑制剂的最新发展:设计策略,结构-活性关系和机械洞察力

Atamjit Singh1, Karanvir Singh1, Aman Sharma1

  • 1Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.

Chemistry & biodiversity
|July 2, 2024
PubMed
概括

1,2,3-三醇支架显示出开发新的α-葡萄糖酶抑制剂来对抗糖尿病的前景. 本综述分析了基于三醇的化合物,以改善抗糖尿病药物发现.

关键词:
一,二,三二醇是什么? 1,2,3-三二醇是什么?这是一种抗糖尿病药物.糖尿病是一种糖尿病.吃饭后的高血糖症 吃饭后的高血糖症α-葡萄糖化酶的使用.

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Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues09:27

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Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
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α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
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