相关实验视频

Updated: Jun 22, 2025

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Published on: February 7, 2018

内源Fe2+触发的自我准纳米细胞用于自我放大细胞内氧化应激

Zhongxiong Fan¹, Guoyu Xia¹, Qingluo Wang¹

¹School of Pharmaceutical Sciences and Institute of Materia Medica, Xinjiang University, Urumqi, China.

Animal models and experimental medicine

|July 2, 2024

概括

阿特苏纳酸-氨酸纳米细胞通过CD44受体向增强乳腺癌细胞的吸收和杀死. 这种新型药物输送系统有效地产生有毒的基因,抑制瘤生长 in vivo.

科学领域:

纳米医学是一种纳米医学.
癌症治疗方法癌症治疗方法
药物输送系统药物输送系统

背景情况:

阿特苏纳酸 (ASA) 产生有毒的氧基,但在纳米药物配方中受到细胞内传递不良的影响.
铁 (Fe2+) 催化了ASA的分解,释放了活性氧物种.

研究的目的:

开发一种新的纳米细胞 (NM) 系统,以改善Artesunate (ASA) 的细胞内输送.
为了提高ASA在向和治疗乳腺癌细胞的有效性.

主要方法:

通过化形成ASA-氨酸 (HA) 结合物.
两性ASA-HA的自组合结合在水性环境中成为自我向的纳米细胞 (NM).
利用CD44受体介导的细胞转移来增强细胞吸收.

主要成果:

通过向CD44受体,ASA-HA NMs显著增强了乳腺癌细胞的吸收.
细胞内释放的ASA被内源Fe2+催化,产生有毒的氧基,导致瘤细胞死亡.
在体内实验证实了持续的瘤生长抑制.

结论:

自我向的纳米细胞 (NM) 提供了一个有前途的策略,以改善基于Artesunate (ASA) 的癌症治疗.
这种方法利用临床批准的药物来加速瘤学药物开发.
针对CD44的NM系统增强了ASA的输送和疗效,为临床研究铺平了道路.

关键词:

它们是纳米微粒.没有芬顿的非芬顿氧化应激是一种氧化应激.有活性氧物种的反应性氧物种.自己定位的目标.

更多相关视频

Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS

Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS

Published on: December 21, 2011

Detection of Total Reactive Oxygen Species in Adherent Cells by 2',7'-Dichlorodihydrofluorescein Diacetate Staining

Detection of Total Reactive Oxygen Species in Adherent Cells by 2',7'-Dichlorodihydrofluorescein Diacetate Staining

Published on: June 23, 2020

相关概念视频

Electron Transport Chain: Complex I and II

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...

Electron Transport Chain: Complex III and IV

Electron Transport Chain: Complex III and IV

During the electron transport chain, electrons from NADH and FADH2 are first transferred to complexes I and II, respectively. These two complexes then transfer the electrons to ubiquinol, which carries them further to complex III. Complex III passes the electrons across the intermembrane space to Cyt c, which carries them further to complex IV. Complex IV donates electrons to oxygen and reduces it to water. As electrons pass through complexes I, III, and IV, the energy released aids the pumping...