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慢性病猫的食补充剂:一个潜在的双盲随机对照试验
Pak-Kan Tang1, Dirk Hendrik Nicolaas van den Broek2, Rosanne E Jepson3
1Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, United Kingdom.
Journal of veterinary internal medicine
|July 2, 2024
概括
患有慢性病 (CKD) 的猫的补充剂可以帮助管理矿物骨疾病 (CKD-MBD). 富含的酸盐限制饮食 (PRD) 稳定了关键变量,并预防了患有CKD的猫的高血症.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 营养科学 营养科学
背景情况:
- 血总 (tMg) 是猫类慢性病 (CKD) 的预后指标.
- 患有CKD的猫的低磁血与更短的存活时间有关.
- 食补充剂对修改这种危险因素的潜力尚不清楚.
研究的目的:
- 为了研究丰富的酸盐限制饮食 (PRD) 对猫的CKD-矿物骨疾病 (CKD-MBD) 变量的影响.
- 评估食补充剂是否可以影响血总,电离和FGF23度.
主要方法:
- 一个前性的,双盲的,并行组随机试验,涉及60只患有体性CKD的猫.
- 猫在PRD上得到稳定,然后被缩PRD (n=27) 或对照PRD (n=33) 养.
- 使用线性混合效应模型分析临床病理变量,并进行治疗意图和每协议分析.
主要成果:
- 被丰富PRD养的猫的血总 (tMg) 显著增加 (β = 0.25 ± 0.07 mg/dL/月;P < .001).
- 血电离 (iCa) 的变化速度在各组之间有所不同,富含组的变化趋势下降,对照组的变化趋势上升.
- 血纤维细胞生长因子-23 (FGF23) 在补充的组中保持稳定,但在对照组显著增加.
结论:
- 富含的PRD是一种可行的治疗策略,用于治疗猫的CKD-MBD.
- 这种饮食方法有助于稳定血FGF23度.
- 在PRD中补充,可以有效地预防CKD猫的高血症.
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