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甲状腺组织形态学可以识别PTEN hamartoma瘤综合征的患者吗?
Melad N Dababneh1, Laura Rabinowitz1, Gilman Plitt2,3
1Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Histopathology
|July 2, 2024
概括
甲状腺历史形态PHTS评分 (THiPS) 系统识别了酸酶和张素同类物 (PTEN) 瘤瘤综合征 (PHTS) 患者的甲状腺疾病. 这种评分系统有助于诊断PHTS相关的甲状腺疾病.
科学领域:
- 内分泌学 在内分泌学.
- 遗传学 遗传学 是一个
- 在瘤学瘤学.
背景情况:
- 酸酶和张素同类物 (PTEN) 哈马瘤瘤综合征 (PHTS) 是一种与各种癌症风险增加相关的遗传疾病.
- 甲状腺异常,包括毛囊结节性疾病 (FND) 和毛囊细胞衍生的癌症,在PHTS患者中很常见.
- 准确的组织病理学评估对于识别患有PHTS的个体,这些人有患甲状腺恶性瘤的风险至关重要.
研究的目的:
- 开发和验证PHTS患者甲状腺样本的组织形态评分系统.
- 为了区分PHTS患者的甲状腺疾病与非PHTS对照患者的甲状腺疾病,并具有相似的组织病理发现.
- 评估PTEN免疫组织化学的实用性与PHTS诊断的组织形态特征相结合.
主要方法:
- 从30名PHTS患者和31名患有FND的对照患者的甲状腺切除样本进行了回顾性分析.
- 评估特定的组织学标准,包括结节类型,脂质形形质,甲状腺炎,细胞质清除,结节内结节的外观和核异型.
- 甲状腺组织形态学PHTS评分 (THiPS) 系统的开发和PTEN免疫组织化学表达的评估.
主要成果:
- 具有4或更高的截止值的THiPS系统识别了90%的PHTS病例和16.1%的对照病例.
- 在96%的PHTS病例中观察到PTEN表达的丧失,而对照组中只有12%.
- 在PHTS患者中的常规乳头甲状腺癌保留了PTEN细胞质表达,使其与其他PHTS相关的甲状腺病变区别开来.
结论:
- 虽然THiPS系统并不完全特定,但在检测PHTS患者的甲状腺样本时具有很高的灵敏度.
- 通过THiPS量化的特定组织学特征的组合在PHTS患者中更为频繁.
- 组织病理学评估和THiPS系统是管理PHTS患者甲状腺疾病的宝贵工具.
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