固酶-5抑制剂和痴呆风险:一个真实世界的研究
Naomi Gronich1,2, Nili Stein1, Walid Saliba1,2,3
1Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.
Neuroepidemiology
|July 2, 2024
概括
固酶-5抑制剂 (PDE5i) 在现实数据中没有显示与降低痴呆风险的相关性. 这项研究没有发现PDE5抑制剂降低患痴呆症的可能性的证据.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 有限的生物学和流行病学数据表明,代酶-5抑制剂 (PDE5i) 可能会降低痴呆风险.
- 需要现实世界的数据来确认PDE5i使用与痴呆症预防之间的关联.
研究的目的:
- 通过使用现实世界的数据,调查固酶-5抑制剂 (PDE5i) 与痴呆风险之间的关联.
- 分析PDE5i在不同患者队列中的潜在神经保护作用.
主要方法:
- 使用以色列最大的医疗保健提供商 (2005-2023) Clalit 的数据进行了回顾性队列研究.
- 分析了两个队列:用于良性前列腺缩 (BPH) 的tadalafil使用者与α-1阻断剂使用者匹配,以及与/没有PDE5i治疗的勃起功能障碍患者.
- 使用倾向性得分匹配和时间依赖性分析,对痴呆症的发生进行了到2023年5月的随访.
主要成果:
- 在塔达拉菲尔队列 (5,204名用户与18,565名匹配对照) 中,在塔达拉菲尔使用和痴呆风险 (HR = 0.99) 之间没有发现任何关联.
- 在勃起功能障碍队列 (133,336名患者) 中,PDE5i的使用与平均随访7.9年 (HR = 0.95) 的痴呆症风险降低无关.
- 敏感性分析,包括限制老年患者或按PDE5i类型分层,产生了一致的结果.
结论:
- 使用固酶-5抑制剂与痴呆症风险降低无关.
- 目前的现实世界证据不支持PDE5i能提供对痴呆症的保护的假设.
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