一项为期4年的回顾性研究:XEN45在患有青光眼的患者中的临床结果
María Pilar Bambó1,2, Álvaro Tello1,2, María José Vicente1,2
1Miguel Servet University Hospital, Zaragoza, Spain.
Ophthalmic research
|July 2, 2024
概括
XEN45植入物有效降低眼内压力 (IOP),并减少长期内光眼患者的药物需求. 无论是独立的XEN45还是与白内障手术结合的XEN45,都显示出显著的IOP降低.
科学领域:
- 眼科医生 眼科 眼科
- 医疗器械 医疗器械
- 青光眼治疗方法 青光眼治疗方法
背景情况:
- 眼管理需要有效的长期策略来控制眼内压力 (IOP).
- XEN45植入物是对玻璃眼患者的一种最小侵入性选择.
- 评估其长期有效性和安全性,单独或与白内障手术一起,至关重要.
研究的目的:
- 评估XEN45植入物的长期有效性和安全性.
- 为了比较XEN45植入物单独使用与白内障手术结合使用的结果.
- 评估对眼内压力 (IOP) 和药物使用的影响.
主要方法:
- 一个回顾性,单中心研究包括来自176名绿眼病患者的206只眼睛.
- 患者单独接受XEN45植入物或与发泡乳化 (白内障手术) 结合.
- 从2016年11月到2021年10月收集的数据,IOP降低作为主要终点.
主要成果:
- 在第4年,XEN45植入物显著降低了平均IOP,从20.5 ± 5.0 mmHg降至15.8 ± 4.4 mmHg (p < 0.0001).
- 单独使用XEN45和XEN45+法化组都显示出长期显著的IOP降低.
- 在手术后,眼部低血压药物的数量显著下降,从2.6降至1.3药物.
结论:
- 植入XEN45植入物,与或没有白内障手术,提供显著的长期IOP减少.
- 它有效地减少了对眼部低血压药物的依赖.
- 该程序显示了良好的安全性,并有可控的并发症.
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