老年住院患者的相角和药物数量之间的相关性:一个横截面研究
Toshiyuki Moriyama1,2, Mizuki Tokunaga2, Ryoko Hori2
1National Hospital Organization Fukuokahigashi Medical Center, Fukuoka, Japan.
Annals of geriatric medicine and research
|July 2, 2024
概括
服用更多药物的老年人显示细胞健康状况下降,由较低的相角 (PhA) 表示. 这表明需要审查老年护理中的药物治疗方案,以保持肌肉质量和整体健康.
科学领域:
- 老年医学 老年医学
- 细胞生理学 细胞生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肌肉衰弱是老年人的一个重大问题,增加死亡风险和降低生活质量.
- 阶段角 (PhA) 作为细胞健康和细胞完整性的生物标志物.
- 多药在老年人群中很普遍,可能会影响像PhA这样的细胞健康指标.
研究的目的:
- 在老年住院患者中,研究药物数量和多药与相角 (PhA) 之间的关联.
- 确定多种药物是否有助于降低肌肉质量,使用PhA作为生物标志物.
主要方法:
- 一项回顾性横截面研究分析了517名需要康复的老年住院患者 (≥65岁) 的数据.
- 用生物电阻分析测量相角 (PhA).
- 药物数量和多种药物 (≥5种药物) 在入院时被记录下来,并使用多变量线性回归分析,调整为共变量.
主要成果:
- 在男性和女性中,药物数量和PhA之间观察到显著的负相关性.
- 虽然多药在PhA中表现出负面趋势,但该关联在男性中没有统计学意义,但在女性中接近显著.
- 在34.4%的参与者中诊断出了sarcopenia,66%的人服用多药.
结论:
- 在老年住院患者中,入院时处方药物的数量与相角 (PhA) 有负相关性.
- 研究结果强调了老年护理中药物审查和管理的重要性,以潜在地减轻对细胞健康和肌肉质量的负面影响.
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