冷的肩膀和帕金森病的风险:丹麦基于登记册的队列研究
Nadia R Gadgaard1, Katalin Veres1, Victor W Henderson1,2,3
1Department of Clinical Epidemiology, Aarhus University Hospital and Aarhus University, Aarhus, Denmark.
Clinical epidemiology
|July 2, 2024
概括
冷的肩膀可能表明患帕金森病 (PD) 的风险增加. 这项研究表明,冷的肩膀可能是PD的早期临床前症状,可能有助于早期检测和查.
科学领域:
- 神经学 神经学
- 整形外科 整形外科 整形外科
- 流行病学 流行病学
背景情况:
- 冷的肩膀是帕金森病 (PD) 的潜在早期,临床前指标.
- 调查冷肩和随后的PD风险之间的关联对于早期诊断至关重要.
研究的目的:
- 为了评估帕金森病 (PD) 风险在冷肩诊断后.
- 评估冷肩作为帕金森症的潜在早期表现和PD查的目标.
主要方法:
- 利用丹麦基于人口的登记 (1995-2016) 来识别40岁以上的新发结肩病患者.
- 在冷肩患者中的PD发病率与一般人群和背部疼痛队伍的比较.
- 估计的累积发病率和调整的危险比率 (HRs) 具有95%的置信区间 (CI).
主要成果:
- 确定了37,041例冷肩病例,370,410例一般人口对照病例和111,101例背部疼痛对照病例.
- 冷肩队列显示,累计PD发病率为1.51%相对于0-22岁的一般人口的1.03%.
- 经调整的PDHR为1.45 (CI:1.24-1.70) 对于冷的肩膀与0-22岁的一般人群.
结论:
- 冷的肩膀与帕金森病 (PD) 的风险增加有关,尽管绝对风险仍然很低.
- 结的肩膀可能代表了PD的早期表现,表明了查的潜力.
- 检测偏差不太可能解释观察到的PD风险的长期增加.
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