儿科癌症患者的质子束疗法和dentofacial发展:一个范围审查
Emma Foster-Thomas1, Marianne Aznar2, Bernadette Brennan3
1NIHR Doctoral Fellow in Restorative Dentistry, Manchester University NHS Foundation Trust, UK.
International journal of particle therapy
|July 2, 2024
概括
针对头癌的儿科质子束疗法 (PBT) 可以导致dentofacial发育障碍. 需要更多的研究来了解PBT对儿童癌症幸存者的面部发育和牙异常的影响.
科学领域:
- 儿科瘤学 儿科瘤学
- 辐射瘤学 辐射瘤学
- 头骨面部的发展
背景情况:
- 儿童对头部和部的辐射疗法可能会扰乱牙和面部的发育.
- 这是小儿癌症存活率的一个研究不足的领域.
研究的目的:
- 审查关于质子束疗法 (PBT) 对儿科癌症患者牙面部发育的影响现有证据.
- 为了确定当前研究中关于PBT对面结构的影响的差距.
主要方法:
- 对已发表和未发表的研究进行了全面的文献搜索.
- 摘要的初始选由一名审查员进行,由两名独立审查员进行二次选和数据提取.
- 使用叙事综合方法来分析研究结果.
主要成果:
- 在选了82个记录后,包括了11篇文章.
- 观察到研究设计和报告质量的显著异质性.
- 患者数量有限和报告不足使得无法就影响面部变形或牙异常的因素得出明确的结论.
结论:
- 牙面部发育障碍是治疗PBT的小儿头癌幸存者的报告不足的毒性.
- 进一步的研究是必不可少的,以调查治疗年龄,辐射剂量和并发疗法对dentofacial毒性和生活质量的影响.
更多相关视频
07:57Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
Published on: March 24, 2022
2.8K
05:18Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant
Published on: October 6, 2023
1.3K
相关概念视频
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K