适应皮肤菌株促进了Staphylococcus aureus的抗生素耐受性
bioRxiv : the preprint server for biology
|July 2, 2024
概括
皮肤酵母 Malassezia sympodialis 通过分泌杀菌化合物来抑制金黄色葡萄球菌的殖民. 细菌对这种酵母的耐受性进化也赋予了多药性耐药性,揭示了菌群相互作用和抗生素敏感性之间的联系.
科学领域:
- 微生物学 微生物学
- 菌类学 菌类学是指菌类学.
- 细菌学 细菌学是一门学科.
背景情况:
- 人的皮肤是稳定的真菌生物群的庇护所,主要是马拉塞西亚酵母.
- 菌群生物在抑制病原体殖民中的作用尚不清楚.
研究的目的:
- 为了研究马拉塞西亚sympodialis如何影响黄金葡萄球菌在人体皮肤上的殖民.
- 确定细菌适应真菌对抗性的机制及其对抗生素耐药性的影响.
主要方法:
- 在人体皮肤模型上对马拉塞西亚sympodialis和金黄色葡萄球菌的共同培养实验.
- 对M. sympodialis分泌产物的细菌杀菌活性进行分析.
- 试验S. aureus的进化以适应M. sympodialis的对抗性.
- 对S. aureus变种的遗传分析,重点关注严格反应调节器Rel.
主要成果:
- Malassezia sympodialis的殖民化显著减少了金黄色葡萄球菌 (Staphylococcus aureus) 的皮肤殖民.
- M. sympodialis 分泌的产品表现出对S. aureus的杀菌活性,由酸性条件和自由脂肪酸增强.
- 在S. aureus中严格响应调节器Rel的突变赋予了M. sympodialis的耐受性.
- 实验室进化和自然的Rel变体都对M. sympodialis和临床抗生素表现出交叉耐受性.
结论:
- 皮肤菌群,特别是马拉塞西亚,可以调解对S. aureus等细菌病原体的殖民抵抗力.
- 细菌对真菌对抗的适应涉及诸如严格响应调节等机制.
- 菌-细菌相互作用可以影响病原体的抗生素敏感性,突出显示微生物群在耐药性进化中的作用.
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