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Updated: Jun 22, 2025

A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects TEdeff in Cancers
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A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects TEdeff in Cancers

Published on: September 26, 2019

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针对性降解CDK9可能会破坏MYC转录网络

Mohammed A Toure, Keisuke Motoyama, Yichen Xiang

    bioRxiv : the preprint server for biology
    |July 2, 2024
    PubMed
    概括

    针对性降解循环素依赖激酶9 (CDK9) 通过防止补偿反机制,有效抑制MYC驱动的增殖,而不是抑制. 这种方法为异常细胞生长提供了卓越的治疗潜力.

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