通过使用正统相关性分析和部分最小方程在ABCD样本中发现的大脑行为关系的稳定性和可重现性进行比较
Hajer Nakua1,2, Ju-Chi Yu1, Hervé Abdi3
1Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Network neuroscience (Cambridge, Mass.)
|July 2, 2024
概括
准则相关性分析 (CCA) 和部分最小平方相关性 (PLS) 方法揭示了大脑行为联系的不同稳定性. 美国国家卫生研究院工具箱数据显示了可重现的结果,与儿童行为检查清单数据不同.
科学领域:
- 神经科学是一个神经科学.
- 生物统计学 生物统计学
- 发展心理学 发展心理学
背景情况:
- 准则相关性分析 (CCA) 和部分最小平方相关性 (PLS) 是用于识别两个数据矩阵之间的线性关联的统计方法.
- 这些方法计算潜在变量 (LVs),最大化相关性 (CCA) 或共变量 (PLS),提供对复杂关系的见解.
研究的目的:
- 为了比较来自CCA和PLS的脑行为关系的相似性和概括性.
- 评估这些关系的稳定性和可重复性,在一个大的儿科队列中,在不同的表型测量中进行测量.
主要方法:
- 使用了青少年大脑认知发展 (ABCD) 数据集 (N > 9,000,年龄9-11).
- 大脑数据包括皮质厚度估计 (Desikan-Killiany地图).
- 行为数据包括儿童行为检查清单 (CBCL) 分量和NIH工具箱绩效评分,分别分析.
- 再抽样方法评估了潜变量 (LVs) 的意义和概括性.
主要成果:
- 对于CBCL-大脑关系的初级LV (LV1) 是显著的,但在CCA和PLS模型之间缺乏一致的稳定性和可重复性.
- 对于NIH工具箱-大脑关系的LV1,在CCA和PLS中表现出类似的模式,表现出稳定性和可重复性.
- 现象类型测量的统计差异影响了确定的大脑行为关系的稳定性.
结论:
- 选择的表型测量显著影响的稳定性和可重复性的大脑行为协会,通过CCA和PLS在儿科群体中确定.
- 这些发现强调了在解释发育神经科学中多变量关联分析结果时考虑数据特征的重要性.
相关概念视频
Steady Flow of a Fluid Stream
Consider a control volume, such as a pipe with solid boundaries, through which fluid flows and changes direction due to the impulse exerted by the resulting force from the pipe walls. In steady flow, the mass of fluid entering the control volume at a given time, t, with velocity v1, is equal to the mass leaving after infinitesimal time dt, with velocity v2.
During this process, the momentum of the fluid within the control volume remains constant over the time interval dt. By applying the...
During this process, the momentum of the fluid within the control volume remains constant over the time interval dt. By applying the...
Conservation of Mass in Moving, Nondeforming Control Volume
Stormwater detention basins are essential in managing runoff during heavy rainfall, particularly in urban areas where impervious surfaces increase the risk of flooding. Understanding the conservation of mass in these systems allows engineers to optimize basin performance, balancing inflow, outflow, and water storage.
In the context of a detention basin, the conservation of mass states that the total mass of water entering the basin must equal the mass leaving the basin plus any accumulation of...
In the context of a detention basin, the conservation of mass states that the total mass of water entering the basin must equal the mass leaving the basin plus any accumulation of...
Typical Model Studies
Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
Design Example: Creating a Hydraulic Model of a Dam Spillway
Scaled hydraulic models of dam spillways provide a practical way to replicate and study the intricate flow dynamics of these structures. Often built to a 1:15 ratio, these models allow for observing critical water behavior, such as velocity distribution, flow patterns, and energy dissipation.
Gradually Varying Flow
Gradually varying flow (GVF) in open channels describes situations where water depth changes slowly along the channel due to factors like non-uniform bed slope, channel shape variations, or obstructions. This flow type occurs when the depth adjusts gradually to balance gravitational forces, shear forces, and energy requirements, resulting in a low rate of depth change.Characteristics of Gradually Varying FlowGVF is commonly observed in natural streams, rivers, and canals, where flow depth...
Rapidly Varying Flow
Rapidly varying flow (RVF) in open channels is characterized by abrupt changes in flow depth over a short distance, with the rate of depth change relative to distance often approaching unity. These flows are inherently complex due to their transient and multi-dimensional nature, making exact analysis difficult. However, approximate solutions using simplified models provide valuable insights into their behavior.Key Features of Rapidly Varying FlowRVF is commonly observed in scenarios involving...


