素功能化纳米级共价有机框架作为纳米载体,用于pH响应药物递送,增强抗癌活性
Datian Fu1, LiLi Zhong2, Jin Xu3
1Department of Pharmacy, Hainan Women and Children's Medical Center Haikou Hainan 570312 China.
RSC advances
|July 2, 2024
概括
本研究介绍了针对癌症治疗的pH响应纳米级共价有机框架 (NCOF). 这些新型药物输送纳米载体显示了药物释放的增强和对癌细胞的有效性.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 纳米级共价有机框架 (NCOFs) 是有前途的药物递送纳米载体.
- 有限的研究存在于pH响应的NCOFs用于药物输送.
- 响应刺激的纳米载体对于向癌症治疗至关重要.
研究的目的:
- 为高效的癌症治疗设计和合成pH响应的NCOF.
- 开发一种具有触发药物释放的药物输送系统.
- 在体外评估功能化NCOF的治疗潜力.
主要方法:
- 通过合成后修饰NCOFs的化装饰,以创建NCOFs-NHNH2.
- 在NCOFs-NHNH2上对多克索鲁比 (DOX) 的共价负荷形成NCOFs-NN-DOX.
- 用大豆脂 (SP) 进行表面涂层,以获得NCOFs-NN-DOX@SP,以提高生物相容性.
- 在不同的pH值 (5.2和7.4) 下评估药物释放特征.
- 在体外评估NCOFs-NN-DOX@SP细胞毒性,并在易斯肺癌 (LLC) 细胞中进行成像.
主要成果:
- 与pH 7.4相比,NCOFs-NN-DOX@SP在pH 5.2时的药物释放量增加了六倍.
- 该纳米载体在生理溶液中表现出增强的生物相容性,可分散性和稳定性.
- 实验室试验显示,对LCL细胞的治疗效果有所改善.
- 这种材料作为一种智能,持续释放系统而起作用.
结论:
- 开发的酸装饰的NCOF充当了有效的pH触发分子开关,用于药物输送.
- NCOFs-NN-DOX@SP显示了对按需癌症治疗的显著潜力.
- 这项工作为设计用于生物医学应用的刺激响应性NCOF提供了一种新的方法.
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