结构分析和血液丰富效应的比较基于安吉丽卡辛尼斯多糖的生物功效
Yunxia Tian1, Xiaorui Shen1, Tingting Hu1
1School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Frontiers in pharmacology
|July 2, 2024
概括
天使的多糖 (APS) 显示出血液补充的潜力. 该研究确定了APS-H2O作为一种强效的血液增强剂,证明了它通过调节小鼠中细胞因子水平来促进血液形成的能力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
- 免疫学 免疫学 免疫学
背景情况:
- 天使是一种传统的中医药,以激活血液的特性而闻名.
- 负责其血效应的特定化合物需要进一步研究.
- 多糖是具有多种药理活动的生物活性成分.
研究的目的:
- 为了分离和表征Angelica sinensis多糖体 (APS).
- 评估APS的体内和体外造血活性.
- 阐明APS的血效应的结构基础.
主要方法:
- 隔离和净化五个同质的APS分数.
- 确定含糖量,分子量,单糖化合物组成和红外光谱.
- 使用乙化 (APH) 和环胺 (CTX) 建立缺血小鼠模型.
- 测量器官指数,血液学和生物化学参数.
- 在体外血液补充活动的评估.
主要成果:
- 在APS治疗中,血清中的红色素 (EPO),花细胞殖民地刺激因子 (G-CSF) 和中白素-3 (IL-3) 的水平升高.
- APS降低了瘤死亡因子-α (TNF-α) 水平,表明了免疫调节作用.
- 在体外,APS-H2O表现出最强的血液增强活性,而APS-0.4表现出最弱的活性.
- 结构分析显示,APS-H2O是一种阿拉比诺格拉克坦糖,APS-0.4是一种酸性多糖.
结论:
- 安吉丽卡辛尼斯的多糖,特别是APS-H2O,具有显著的造血活性.
- 通过调节关键细胞因子水平,APS促进了血液形成.
- APS-H2O是血液补充疗法和健康产品的潜在候选者.
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