相关实验视频

Updated: May 4, 2026

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

Published on: April 7, 2014

不同度的氧化重复内内注射对小鼠免疫功能的影响

Sumeng Chen¹, Jingjing Liu¹, Shaoqiang Huang¹

¹Department of Anesthesia, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Frontiers in pharmacology

|July 2, 2024

概括

在小鼠中服用氧化导致显著的体重减轻和减少CD4+T细胞,表明免疫抑制. 这项研究探讨了氧化.

科学领域:

免疫学免疫学免疫学
药理学药理学是指药理学的学科.
神经科学是一个神经科学.

背景情况:

作为阿片类药物激动剂的氧化对免疫功能的影响仍在争论中.
研究氧化对免疫反应和潜在机制的影响至关重要.

研究的目的:

为了检查氧科对小鼠免疫功能的影响.
阐明氧化影响免疫细胞和信号通路的分子机制.

主要方法:

小鼠接受了多次的内注射吗啡或不同剂量的氧化.
分析了T细胞中的淋巴细胞,血清炎症性细胞因子和阿片类受体表达 (MOR, KOR, DOR).
还评估了托尔类受体4 (TLR4) 信号通路的表达.

主要成果:

超过20毫克/公斤的氧化剂量导致显著的体重减轻.
随着氧化的使用,观察到CD4+ T细胞的剂量依赖性下降,而CD8+ T细胞和炎症性细胞因子显示的变化很小.
氧化增加了MOR,KOR,DOR和TLR4信号通路的mRNA表达.

结论:

在老鼠中,重复施用氧化会诱导免疫抑制.
氧化对免疫功能的影响可能涉及阿片类受体和TLR4信号通路的调节.

关键词:

免疫细胞免疫细胞免疫功能免疫功能免疫功能这是吗啡吗啡.在阿片类受体的阿片类受体.氧化的氧化是什么?

更多相关视频

Assessment of Antibody-based Drugs Effects on Murine Bone Marrow and Peritoneal Macrophage Activation

Assessment of Antibody-based Drugs Effects on Murine Bone Marrow and Peritoneal Macrophage Activation

Published on: December 26, 2017

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

相关概念视频

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...