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Updated: Jun 22, 2025

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在线虫编程DNA消除过程中DNA双链断裂的末端切除和端粒愈合

Brandon Estrem1, Richard E Davis2, Jianbin Wang1,3

  • 1Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA.

Nucleic acids research
|July 2, 2024
PubMed
概括

在线虫中的编程DNA消除 (PDE) 依赖于DNA双链断裂 (DSB). 端粒愈合是特定于保留的DSB末端,防止消除并确保在发育过程中确保基因组完整性.

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