儿科奇亚里形中的声带:系统性审查和元分析
Brandon J Vilarello1, Sarah Maurrasse2, Eli Grunstein1,3
1Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
概括
患有阿诺德-奇亚里形的儿童的先天性声带 (VCP) 与症状较早开始时的较差结果有关. 在本系统性审查中,早期干预的时间没有显著影响恢复.
科学领域:
- 儿科神经学 儿科神经学
- 神经发育障碍 神经发育障碍
- 遗传性缺陷 遗传性缺陷是一种先天性缺陷
背景情况:
- 阿诺德-奇亚里形是婴儿先天性声带 (VCP) 的潜在原因.
- 有限的数据存在于自然史和预后因素的VCP在儿童与奇阿里形.
研究的目的:
- 系统地审查和描述阿诺德-奇亚里形儿童先天性VCP的症状严重程度和解决的预后因素.
- 调查症状发病时的年龄和干预时间与VCP结果之间的关联.
主要方法:
- 系统性审查遵循PRISMA指南,搜索PubMed,科学网络和科克兰图书馆.
- 从176项研究中提取的数据包括发病时的年龄,奇亚里型,干预细节和气管切除术史.
- 统计分析采用了奇平方测试来确定显著的关联.
主要成果:
- 较早出现的斯特里多或VCP症状与较低的症状解消和气管切除术断管的可能性显著相关.
- 症状发作和神经外科干预之间的时间间隔没有显示出与改善结果的显著关联.
结论:
- 由于Arnold-Chiari形导致的VCP二次性,儿童的早期症状发作表明预后较差.
- 进一步的前性研究是必要的,以充分了解自然历史和早期干预的好处.
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