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用万科米辛进行的外科手术期间感染预防是脊椎外科手术中深部手术部位感染的重要危险因素
Gregory S Kazarian1, Jung K Mok, Mitchell Johnson
1Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY.
Spine
|July 2, 2024
概括
塞法索林在脊柱手术后预防感染方面比万科米辛更有效. 与西法林相比,使用万科米辛与术后感染的风险增加了2.5倍.
科学领域:
- 整形外科手术 整形外科手术
- 预防传染病 预防传染病
- 药理学 药理学是指药理学的学科.
背景情况:
- 在脊柱外科手术中,外科手术期间的感染预防非常重要.
- 塞法林替代品在预防中的比较疗效尚未得到充分证实.
研究的目的:
- 为了比较Cefazolin与Vancomycin在初级脊椎手术中进行外科手术期间感染预防的疗效.
主要方法:
- 对10122名接受初级脊柱手术的患者进行了回顾性队列研究.
- 通过灌/除菌,临床怀疑和阳性培养物定义的感染.
- 进行单变量和多变量分析以确定风险因素.
主要成果:
- 总体感染率为0.78%; 0.73%与塞法林相比,2.03%与万科米辛.
- 多变量分析确定非塞法林抗生素 (OR: 2.48) 和BMI是感染的独立风险因素.
- 两种疗法都没有影响Gram类型,生物类型或抗生素耐药性.
结论:
- 与静脉注射的塞法佐林相比,静脉注射的万科米辛与感染风险增加2.5倍有关.
- 建议常规使用IV塞法索林进行预防.
- 除非临床上有指示,否则应避免选择性使用万科米.
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