亚临床甲状腺功能障碍与认知衰退之间的关联:来自ELSA-巴西研究的发现
Natalia Gomes Gonçalves1, Claudia Szlejf2, Paulo Andrade Lotufo2
1Division of Geriatrics, Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
概括
随着时间的推移,即使没有明显的甲状腺功能障碍,自由甲状腺素 (FT4) 水平的微妙变化也与成人加速认知衰退有关. FT4的增加和减少都与记忆力,语言流性和执行功能的更快下降有关.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 甲状腺功能障碍是认知衰退和痴呆症的已知因素.
- 微妙的甲状腺激素变化对认知的具体影响仍然不清楚.
- 这项研究调查了甲状腺激素和认知功能在没有明显甲状腺疾病的个体之间的纵向关系.
研究的目的:
- 检查基线与甲状腺刺激激素 (TSH),自由甲状腺素 (FT4) 和自由三甲状腺素 (FT3) 水平的变化以及认知衰退之间的关联.
- 在没有明显的甲状腺功能障碍的中年和老年人群中,随着时间的推移评估认知表现.
- 为了确定微妙的甲状腺激素变化是否预测认知能力下降.
主要方法:
- 这是一项长度研究,包括9524名35-74岁的参与者,在三个波段 (2008-2019) 中进行了评估.
- 评估了基线TSH,FT4和FT3水平.
- 认知功能每4年评估一次,使用记忆,口语流,执行功能和词识别测试,并获得全球复合z分数.
- 使用线性混合效应模型来分析关联,并根据相关的共变量进行调整.
主要成果:
- 在基线TSH,FT4或FT3水平与认知能力下降之间没有发现任何关联.
- 随着时间的推移,FT4水平的增加与记忆力,语言流性,执行功能和全球认知能力的更快下降相关.
- 随着时间的推移,FT4水平的下降与语言流性和执行功能的更快下降有关.
结论:
- 随着时间的推移,自由甲状腺素 (FT4) 水平的变化,而不仅仅是基线水平,与认知能力下降有关.
- 增加和减少FT4水平都与中年和老年人加速认知衰退有关,而没有明显的甲状腺功能障碍.
- 这些发现强调了监测FT4水平对老年人群认知健康的重要性.
相关概念视频
01:27Language and Cognition
340
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
340
01:26Alzheimer's Disease: Overview
461
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
461
01:20Synthesis and Regulation of Thyroid Hormones
4.5K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.5K
01:30Cognitive Development During Adulthood
87
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
87
01:26Aging
41
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
41
01:30Dementia
110
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
110