多个体质参数对胃肠道或尿道癌症的整体存活率的综合影响:描述性队列研究
Kotaro Sugawara1, Satoru Taguchi2, Wataru Gonoi3
1Department of Gastrointestinal Surgery, Graduate School of Medicine, The, University of Tokyo, Tokyo, Japan.
JPEN. Journal of parenteral and enteral nutrition
|July 2, 2024
概括
将低肌肉质量与其他身体组成问题结合起来,可以改善癌症生存预测. 低的骨肌指数和放射密度显著影响癌症患者的整体存活率.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 老年病的医生 老年病的医生
背景情况:
- 在癌症患者中,越来越多地发现了像低肌肉质量 (sarcopenia),骨髓炎和肥胖等身体构成异常.
- 结合这些参数来预测胃肠道和尿道生殖系统恶性瘤的存活率的预后价值需要进一步调查.
研究的目的:
- 评估是否将低肌肉质量与其他身体组成异常结合起来可以提高生存预测的准确性.
- 在癌症患者中评估骨肌肉指数,骨肌肉辐射密度和脂肪组织指数的独立预后值.
主要方法:
- 2015年经过手术治疗的胃肠道或尿道生殖系统癌症患者的回顾性分析.
- 确定骨肌肉指数,骨肌肉辐射密度和内脏/皮下脂肪组织指数.
- 多变量Cox危险模型和C统计来评估预后能力.
主要成果:
- 这四种身体组成指标都是总体存活率的重要预测指标.
- 低骨肌指数与低骨肌辐射密度相结合,显示5年整体生存率特别差 (50.2%).
- 纳入身体组成参数的模型显示出更好的预测准确性 (c指数从0.68增加到0.72).
结论:
- 骨肌指数低的患者和其他身体组成异常,特别是骨肌辐射密度低的患者的生存结果较差.
- 结合多个身体组成参数可以提高瘤学环境中的死亡率预测.
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