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一种新的STING变异引发了内皮毒性和SAVI疾病

Erika Valeri1,2, Sara Breggion2, Federica Barzaghi2,3

  • 1San Raffaele Telethon Institute for Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute , Milan, Italy.

The Journal of experimental medicine
|July 2, 2024
PubMed
概括

在STING蛋白 (F269S) 的新型突变导致在婴儿期发病的STING相关血管病变 (SAVI),导致全身炎症和器官损伤. 这一发现增强了对疾病中异常STING激活的理解.

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