非侵入性产前检测遵守的种族和种族差异:一个回顾性队列研究
Marco LA Verde1, Maria Maddalena Marrapodi2, Carlo Capristo2
1Department of Woman, Child and General and Specialized Surgery, Luigi Vanvitelli University of Campania, Naples, Italy - marco.laverde@unicampania.it.
Minerva obstetrics and gynecology
|July 2, 2024
概括
非侵入性产前检测 (NIPT) 和第一季度查显示了种族差异. 黑人,亚裔和拉丁裔妇女使用NIPT和查较少,强调需要公平获得产前护理.
科学领域:
- 围产儿医学 围产儿医学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 胎儿形瘤 (三胞胎瘤21,13,18) 是一个重要的产前问题.
- 使用无细胞DNA (cf-DNA) 的非侵入性产前检测 (NIPT) 已经改变了染色体异常查.
- 了解跨不同种族的NIPT坚持是解决产前护理差异的关键.
研究的目的:
- 评估不同族裔的孕妇对非侵入性产前检测 (NIPT) 的遵守情况.
- 根据种族背景,确定产前护理利用的潜在差异.
- 评估不同种族群体对第一季度查协议的遵守情况.
主要方法:
- 意大利一所高等医疗大学医院的一项回顾性单中心研究 (2021年3月至2022年9月).
- 参与者按种族分类 (亚洲/太平洋岛民,黑人,拉丁裔,白人,中东人).
- 对比分析包括单向ANOVA,Tukey的后期测试,以及用于偏差检测的多项回归.
主要成果:
- 在NIPT吸收方面存在显著差异:黑人 (0%),亚洲/太平洋岛民 (9.5%),拉丁裔 (7.5%) 与白人 (27.5%).
- 在黑人 (30.4%的部半透明度,17.4%的综合测试) 和亚裔/拉丁裔群体中观察到较低的第一季度查遵守率.
- 白色怀孕表明,对NIPT和第一季度查方案的遵守率更高.
结论:
- 在非侵入性产前检测 (NIPT) 和第一季度查遵守方面存在显著的种族差异.
- 在多个非白人族群中观察到cf-DNA测试和查的使用率较低.
- 有针对性的干预和政策对于减少障碍和确保所有妇女平等获得产前护理至关重要.
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