乙氨基诱导的高阴离子间代谢酸化:一种潜在的未被认可的后果,来自于常见的药物治疗
Dhruv Gaur1, Michael G Michalopulos1, Keri A Drake1
1Division of Pediatric Nephrology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, 75390, USA.
Pediatric nephrology (Berlin, Germany)
|July 2, 2024
概括
本案例报告详细介绍了一名患有慢性病 (CKD) 的患者,由于使用乙氨基,他患上了一种罕见的代谢性酸性疾病. 它强调了一个具有挑战性的诊断,即使是标准药物剂量.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床毒理学 临床毒理学
- 内部医学 内部医学
背景情况:
- 代谢性酸化是慢性病 (CKD) 的常见并发症.
- 慢性病患者代谢酸性的不常见原因在诊断上可能具有挑战性.
- 乙氨基的使用可能导致获得的5-oxoprolinemia,这是一种罕见的高阴离子间隙代谢酸症的原因.
研究的目的:
- 描述一个患有慢性脏病的患者在腹腔透析中使用乙氨基二次获得的5-oxoprolinemia的病例.
- 要突出在CKD中不常见的代谢性酸性病变病因的诊断挑战.
- 要强调的是,5-oxoproline的积累甚至可以发生在治疗性乙氨基剂量在CKD患者.
主要方法:
- 案例报告. 情况报告.
- 临床病例审查.
- 分析患者的新陈代谢概况和药物治疗史.
主要成果:
- 一名患有CKD的腹腔透析患者患有高离子隙代谢酸性化症.
- 这种酸性病被归因于由于使用乙氨基而获得的5-oxoprolinemia.
- 尽管患者服用了治疗剂量的乙氨基,但5-oxoproline的积累发生了.
结论:
- 获得的5-oxoprolinemia是使用乙氨基的罕见但严重并发症,特别是在CKD患者中.
- 慢性病构成了发展5-oxoprolinemia的危险因素.
- 这一案例强调了在对CKD患者的代谢性酸性疾病的差异诊断中考虑乙氨基诱导的5-oxoprolinemia的重要性,即使使用标准剂量.
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