配方,优化和in-vivo表征热敏的局部鼻凝载有巴科赛德a治疗的治疗
Someshwar Dattatray Mankar1, Shraddha Ranjan Parjane2, Suhas Shivaji Siddheshwar2
1Pravara Rural College of Pharmacy, Pravaranagar, Loni (Bk), Ahmednagar, Maharashtra, 413736, India. sdmankar655@gmail.com.
AAPS PharmSciTech
|July 2, 2024
概括
这项研究开发了一种针对BACOSIDE A输送的优化热敏in-situ鼻凝,提高了生物可用性. 鼻凝配方通过减少发作的发生和强度,显示出对治疗的希望.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药物输送系统 药物输送系统
- 神经科学是一个神经科学.
背景情况:
- 内鼻途径通过绕过第一通代谢,提供卓越的全身生物利用性.
- 巴科帕蒙尼耶里 (Brahmi) 传统上用于认知增强,并具有潜在的抗作用.
- 化物A是Bacopa monnieri中的主要活性化合物.
研究的目的:
- 开发和优化一种热敏的in-situ鼻凝,用于Bacoside A的输送.
- 评估鼻凝在治疗中的潜力.
主要方法:
- 为了优化配方,使用了3 ^ 2的因数设计.
- 分别使用Poloxamer 407和HPMC K4M作为热凝固剂和粘粘剂.
- 进行了ex-vivo透研究和in-vivo模型 (PTZ诱导的).
主要成果:
- 优化的配方F7显示出94.69%的活体鼻透率和30.48°C的sol-gel过渡.
- 凝温度和粘粘性强度是影响性能的关键因素.
- 优化的鼻凝在体内显著降低了发作的发生和强度.
结论:
- 优化的 in-situ 鼻凝 (F7) 是一种有前途的系统,可以通过鼻子输送 Bacoside A.
- 这种配方增强了生物可用性,并证明了治疗的潜在疗效.
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