相关实验视频

Updated: Jun 22, 2025

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

整合分子途径与全基因组关联数据,以确定乳腺癌的因果关系

Yan-Shuang Li¹, Hong-Chuan Jiang²

¹Department of Breast Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.

Discover oncology

|July 2, 2024

概括

酸盐代谢与乳腺癌 (BC) 风险有因果关系. 像ADH1B和ACSS2这样的关键基因在BC发育中至关重要,并确定了潜在的药物标.

科学领域:

在瘤学瘤学.
代谢学代谢学代谢学
生物信息学是一种生物信息学.

背景情况:

乳腺癌 (BC) 是一个重要的全球健康问题.
了解BC的代谢基础对于开发新的治疗策略至关重要.

研究的目的:

研究酸盐代谢与乳腺癌 (BC) 风险之间的因果关系.
阐明关键代谢基因在BC发育中的分子作用.
确定BC.潜在的治疗点和药物.

主要方法:

使用GEO数据集 (GSE54002,GSE70947,GSE22820) 的差异基因表达分析.
功能和路径丰富分析 (GO,KEGG).
门德尔随机化 (MR) 分析以确定因果关系.
药物基因相互作用分析 (DGIdb) 和ceRNA网络构建.

主要成果:

在BC.中鉴定了1127个差异表达基因 (DEGs).
丰富分析突出了线粒细胞核分裂,细胞外基质和包括PI3K-Akt信号传递和pyruvate代谢在内的途径.
核磁共振分析证实了pyruvate代谢与BC风险之间的因果关系.
构建了涉及关键基因 (ADH1B,ACSS2,ACACB,ADH1A,ALDH2,ADH1C),向药物和ceRNA相互作用的调节网络.

结论:

建立了pyruvate代谢和乳腺癌风险之间的因果关系.
突出了ADH1B,ACSS2,ACACB,ADH1A,ALDH2和ADH1C在通过酸盐代谢的BC病原体中的重要作用.
确定了针对性BC治疗的潜在小分子药物.

关键词:

乳腺癌是什么? 乳腺癌是什么?门德尔的随机化路径基因的路径基因皮鲁酸盐的代谢过程针对性的药物针对性的药物

更多相关视频

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

相关概念视频

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...